Studies & Milestones

April 2026

study

14th Study

Nanoemulsion-Enhanced Cardiac Delivery of Omega-3 Fatty Acids
Reduces Myocardial Fibrosis and Improves Diastolic Function in a Murine HFpEF Model.

Kati Frid, Yair Rokach, Orli Binyamin, Tsipora Markovitz-Patcher, Alicia I. Leikin-Frenkel,
Liraz Larush, Shlomo Magdassi, Rabea Asleh, and Ruth Gabizon. Precis. Nanomed. 2026, 9(2):1801-1814

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November 2024

study

13th Study

Non-Categorical Analyses Identify Rotenone-Induced ‘Parkinsonian’ Rats Benefiting from Nano-Emulsified Punicic Acid (Nano-PSO) in a Phenotypically Diverse Population: Implications for Translational Neurodegenerative Therapies.

Jennifer Viridiana Sánchez-Camacho ,Margarita Gómez-Chavarín , Nuria Galindo-Solano, Patricia Padilla-Cortés , José Luis Maldonado-García, Gilberto Pérez-Sánchez , Lenin Pavón , Jesús Ramírez-Santos , Gabriel Roldán Roldán, Modesto Gómez-López and Gabriel Gutierrez-Ospina, Int. J. Mol. Sci. 2024, 25(23), 12635

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November 2024

study

12th Study

Efficacy of Omega-5 NanoPSO Treatment in the Hippocampus, Through Antioxidant Mechanisms, After an Ischemia/Reperfusion Injury, in Murine Model

Irene Guadalupe Aguilar-García, Jonatan Alpirez, José Francisco Munoz-Valle , Walter Ángel Trujillo-Rangel, David Fernández-Quezada , Sergio Horacio Duenas-Jiménez, María de la Luz Galvan-Ramírez, María Guadalupe Sánchez-Parada , Ana Elizabeth González-Santiago , Judith Marcela Duenas-Jiménez and Rolando Castaneda-Arellano. Antioxidants 2024, 13, 1353.

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April 2024

study

11th Study

Granagard administration prolongs the survival of human mesenchymal stem cells transplanted into a mouse model of multiple sclerosis.

Frid K, Usmann A, Markovits-Pachter T, Binyamin O, Petrou P,
Kassis I, Karussis D, Gabizon R.

J Neuroimmunol. 2024 Apr 15;389:578313. doi: 10.1016/j.jneuroim.2024.578313.
Epub 2024 Feb 14.

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April 2023

NanoGard Omega 3

Launch of NanoGard Omega 3 Development and Marketing.

Febuary 2023

GranaGard Nano-Omega 5 Drops

Launch of GranaGard Omega 3 drops, Development and Marketing.

April 2022

study

10th Study

Nano-PSO Administration Attenuates Cognitive and Neuronal Deficits Resulting from Traumatic Brain Injury.

Qubty D, Frid K, Har-Even M, Rubovitch V, Gabizon R, Pick CG.

Molecules. 2022 Apr 23;27(9):2725. doi: 10.3390/molecules27092725.

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Febuary 2022

study

9th Study

Comparing anti–aging hallmark activities of Metformin and Nano-PSO in a mouse model of genetic Creutzfeldt-Jakob Disease.

Binyamin O, Frid K, Keller G, Saada, Gabizon R.

Neurobiol Aging. 2022 Feb;110:77-87. doi: 10.1016/j.neurobiolaging.2021.11.001.
Epub 2021 Nov 11.

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October 2020

First clinical trial in humans – completed

8th Study

The effect of GranaGard on cognitive indices in MS patients

Beneficial effects of a nano formulation of pomegranate seed oil, Granagard®, on the cognitive function in multiple sclerosis patients.

P. Petrou MD, A. Ginzberg PhD., O. Binyamin PhD. and D. Karussis MD, PhD.

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Research Details – The Ministry of Health’s Clinical Research Website

Presented at a conference of the Israeli Association of Neurology. December 2019

Also presented at the Greek Neuroimmunological Conference, December 2019

September 2020

study

7th Study

Punica granatum L.-derived omega-5 nanoemulsion improves hepatic steatosis in mice fed a high fat diet by increasing fatty acid utilization in hepatocytes

K. Zamora-López, L. G. Noriega, A. Estanes-Hernández, I. Escalona-Nández, S. Tobón-Cornejo, A. R. Tovar, V. Barbero-Becerra & C. Pérez-Monter

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August 2020

study

6th Study

Delay of gCJD aggravation in sick TgMHu2ME199K mice by combining NPC transplantation and Nano-PSO administration.

Neurobiol Aging. 2020 Aug 6;95:231-239. doi: 10.1016/j.neurobiolaging.2020.07.030. Epub ahead of print. PMID: 32861834.

Frid K, Binyamin O, Usman A, Gabizon R.

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December 2019

study

5th Study

Brain targeting of 9c,11t-Conjugated Linoleic Acid, a natural calpain inhibitor, preserves memory and reduces Aβ and P25 accumulation in 5XFAD mice.

Sci Rep. 2019 Dec 5;9(1):18437. doi: 10.1038/s41598-019-54971-9. Erratum in: Sci Rep. 2020 Jan 23;10(1):1320. PMID: 31804596; PMCID: PMC6895090.

Binyamin O, Nitzan K, Frid K, Ungar Y, Rosenmann H, Gabizon R.

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April 2019

study

4th Study

Mitochondrial dysfunction in preclinical genetic prion disease: A target for preventive treatment?

Neurobiol Dis. 2019 Apr;124:57-66. doi: 10.1016/j.nbd.2018.11.003. Epub 2018 Nov 10. PMID: 30423473.

Keller G, Binyamin O, Frid K, Saada A, Gabizon R

.Click here to read the scientific article

December 2018

patent

European patent EP2844265A1 (pending)

Thanks to the unique development based on the most advanced “nanotechnology” in the world today, GranaGard will be granted a European patent.

December 2018

patent

U.S. patent US10154961

Thanks to the unique development based on the most advanced “nanotechnology” in the world today, GranaGard has been granted a U.S. patent.

December 2017

study

3rd Study

Continues administration of Nano-PSO significantly increased survival of genetic CJD mice.

Neurobiol Dis. 2017 Dec;108:140-147. doi: 10.1016/j.nbd.2017.08.012. Epub 2017 Aug 25. PMID: 28847567.

Binyamin O, Keller G, Frid K, Larush L, Magdassi S, Gabizon R.

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January 2017

Launch of GranaGard Nano-Omega 5 Development and Marketing.

GranaGard Nano-Omega 5

The world’s only dietary supplement containing Nano-Omega 5 antioxidant from a natural source.

November 2015

study

2nd Study

Treatment of a multiple sclerosis animal model by a novel nanodrop formulation of a natural antioxidant.

International Journal of Nanomedicine. 2015:10. 7165—7174. 10.2147/IJN.S92704.

Binyamin, Orli & Larush, Liraz & Arush, & Frid, Kati & Keller, Guy & Friedman-Levi, Yael & Ovadia, Haim & Abramsky, Oded & Magdass, Shlomo & Gabizon, Ruth. (2015).

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2014

study

1st Study

Pomegranate seed oil nanoemulsions for the prevention and treatment of neurodegenerative diseases: the case of genetic CJD.

Nanomedicine. 2014 Aug;10(6):1353-63. doi: 10.1016/j.nano.2014.03.015. Epub 2014 Apr 2. PMID: 24704590.

Mizrahi M, Friedman-Levi Y, Larush L, Frid K, Binyamin O, Dori D, Fainstein N, Ovadia H, Ben-Hur T, Magdassi S, Gabizon R.

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May 2013

Establishment of the company

GRANALIX is a biotechnology start-up company, founded by Professor Ruth Gabizon – senior researcher from the Department of Neurology at Hadassah University Hospital, Jerusalem – together with Professor Shlomo Magdassi, an international expert in the field of Nanotechnology from the Casali Center, Institute of Chemistry, at the Hebrew University of Jerusalem.