Studies & Milestones
Comparing anti-aging hallmark activities of Metformin and Nano-PSO in a mouse model of genetic Creutzfeldt-Jakob Disease. Orli Binyamina, Kati Frida, Guy Keller, Ann Saada, Ruth Gabizon.
The effect of GranaGard on cognitive indices in MS patients
Beneficial effects of a nano formulation of pomegranate seed oil, Granagard®, on the cognitive function in multiple sclerosis patients. P. Petrou MD, A. Ginzberg PhD., O. Binyamin PhD. and D. Karussis MD, PhD.
For further reading, a scientific article is attached
Research Details - The Ministry of Health's Clinical Research Website
Presented at a conference of the Israeli Association of Neurology. December 2019
Also presented at the Greek Neuroimmunological Conference, December 2019
Punica granatum L.-derived omega-5 nanoemulsion improves hepatic steatosis in mice fed a high fat diet by increasing fatty acid utilization in hepatocytes K. Zamora-López, L. G. Noriega, A. Estanes-Hernández, I. Escalona-Nández, S. Tobón-Cornejo, A. R. Tovar, V. Barbero-Becerra & C. Pérez-Monter
Delay of gCJD aggravation in sick TgMHu2ME199K mice by combining NPC transplantation and Nano-PSO administration. Neurobiol Aging. 2020 Aug 6;95:231-239. doi: 10.1016/j.neurobiolaging.2020.07.030. Epub ahead of print. PMID: 32861834. Frid K, Binyamin O, Usman A, Gabizon R.
Brain targeting of 9c,11t-Conjugated Linoleic Acid, a natural calpain inhibitor, preserves memory and reduces Aβ and P25 accumulation in 5XFAD mice. Sci Rep. 2019 Dec 5;9(1):18437. doi: 10.1038/s41598-019-54971-9. Erratum in: Sci Rep. 2020 Jan 23;10(1):1320. PMID: 31804596; PMCID: PMC6895090. Binyamin O, Nitzan K, Frid K, Ungar Y, Rosenmann H, Gabizon R.
Mitochondrial dysfunction in preclinical genetic prion disease: A target for preventive treatment? Neurobiol Dis. 2019 Apr;124:57-66. doi: 10.1016/j.nbd.2018.11.003. Epub 2018 Nov 10. PMID: 30423473.Keller G, Binyamin O, Frid K, Saada A, Gabizon R.
Thanks to the unique development based on the most advanced "nanotechnology" in the world today, GranaGard will be granted a European patent.
Continues administration of Nano-PSO significantly increased survival of genetic CJD mice. Neurobiol Dis. 2017 Dec;108:140-147. doi: 10.1016/j.nbd.2017.08.012. Epub 2017 Aug 25. PMID: 28847567.Binyamin O, Keller G, Frid K, Larush L, Magdassi S, Gabizon R.
The world's only dietary supplement containing Nano-Omega 5 antioxidant from a natural source.
Treatment of a multiple sclerosis animal model by a novel nanodrop formulation of a natural antioxidant. International Journal of Nanomedicine. 2015:10. 7165—7174. 10.2147/IJN.S92704. Binyamin, Orli & Larush, Liraz & Arush, & Frid, Kati & Keller, Guy & Friedman-Levi, Yael & Ovadia, Haim & Abramsky, Oded & Magdass, Shlomo & Gabizon, Ruth. (2015).
Pomegranate seed oil nanoemulsions for the prevention and treatment of neurodegenerative diseases: the case of genetic CJD. Nanomedicine. 2014 Aug;10(6):1353-63. doi: 10.1016/j.nano.2014.03.015. Epub 2014 Apr 2. PMID: 24704590. Mizrahi M, Friedman-Levi Y, Larush L, Frid K, Binyamin O, Dori D, Fainstein N, Ovadia H, Ben-Hur T, Magdassi S, Gabizon R.
GRANALIX is a biotechnology start-up company, founded by Professor Ruth Gabizon - senior researcher from the Department of Neurology at Hadassah University Hospital, Jerusalem - together with Professor Shlomo Magdassi, an international expert in the field of Nanotechnology from the Casali Center, Institute of Chemistry, at the Hebrew University of Jerusalem.