Granalix first product, GranaGard, is a submicron self-emulsion formulation of pomegranate seed oil (PSO). PSO contains high concentrations of Punicic Acid (PA), among the strongest natural antioxidants. In the GranaGard formulation, PA has been shown to convert in-vivo into CLA (Conjugated Linoleic Acid), an established neuroprotector and mitochondrial activity modulator.

GranaGard was shown to delay disease onset in a mouse model of genetic prion disease,which presents neurodegenerative features reminiscence of Alzheimer’s disease and to reduce disease burden in a mouse model of Multiple Sclerosis. All components of GranaGard are generally regarded as safe by the FDA.

Granagard is prepared for Granalix by SupHerb (NAZARETH., ISRAEL) Ambrosia-SupHerb is the leading company in Israel in the field of VMS (Vitamins, Minerals, and Supplements).

Researchers:

1. Pomegranate Seed oil nanoemulsions for the prevention and treatment of neurodegenerative diseases: The case of genetic CJD
2. Treatment of a multiple sclerosis animal models by a novel nanodrop formulation of a natural antioxidant
3. Continues administration of Nano-PSO significantly increased survival of genetic CJD mice